• Anti-Dystrophin antibody [34C5] (STJ16101732)

Anti-Dystrophin antibody [34C5] (STJ16101732)

SKU:
STJ16101732-1

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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Dystrophin is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: 34C5
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: Lyophilized
Dilution Range: IHC-P 1:40-1:80
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: DMD
Gene ID: 1756
Uniprot ID: DMD_HUMAN
Immunogen: Prokaryotic recombinant protein corresponding to amino acids 321 to 494 of the dystrophin
Tissue Specificity Expressed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma. Expressed in brain, muscle, kidney, lung and testis. Most tissues contain transcripts of multiple isoforms. Isoform 15: Only isoform to be detected in heart and liver and is also expressed in brain, testis and hepatoma cells.
Function Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.
Protein Name Dystrophin
Database Links Reactome: R-HSA-3000171
Reactome: R-HSA-390522
Cellular Localisation Cell Membrane
Sarcolemma
Peripheral Membrane Protein
Cytoplasmic Side
Cytoplasm
Cytoskeleton
Postsynaptic Cell Membrane
In Muscle Cells
Sarcolemma Localization Requires The Presence Of Ank2
While Localization To Costameres Requires The Presence Of Ank3
Localizes To Neuromuscular Junctions (Nmjs)
In Adult Muscle
Nmj Localization Depends Upon Ank2 Presence
But Not In Newborn Animals
Alternative Antibody Names Anti-Dystrophin antibody
Anti-DMD antibody

Information sourced from Uniprot.org

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