Anti-DYRK1B antibody (331-380 aa) (STJ92801)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human DYR1B at the amino acid range 331-380
General Information
| Short Description | Rabbit polyclonal anti-Dual specificity tyrosine-phosphorylation-regulated kinase 1B (331-380 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DYRK1B |
| Gene ID | 9149 |
| Uniprot ID | DYR1B_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human DYR1B at the amino acid range 331-380 |
| Immunogen Region | 331-380 aa |
| Specificity | Dyrk1B Polyclonal Antibody detects endogenous levels of Dyrk1B protein. |
Additional Info
| Post Translational Modifications | Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization. |
| Function | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance. During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1). |
| Protein Name | Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1bMinibrain-Related KinaseMirk Protein Kinase |
| Database Links | |
| Cellular Localisation | NucleusNucleolusChromosomeLocalizes To Sites Of Double-Strand Breaks (Dsbs) Following Dna Damage |
| Alternative Antibody Names | Anti-Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1b antibodyAnti-Minibrain-Related Kinase antibodyAnti-Mirk Protein Kinase antibodyAnti-DYRK1B antibodyAnti-MIRK antibody |
Information sourced from Uniprot.org