| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IP |
| Reactivity: |
Human/Mouse/Rat/Dog/Pig/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-DYRK1A (N-Term) is suitable for use in ELISA, Western Blot and Immunoprecipitation research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-0.5-2µg/mlELISA-antibody detection limit dilution 1:64000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
DYRK1A |
| Gene ID: |
1859 |
| Uniprot ID: |
DYR1A_HUMAN |
| Immunogen Region: |
N-Term |
| Accession Number: |
NP_001387.2; NP_569120.1; NP_567824.1; NP_569122.1 |
| Specificity: |
This antibody is expected to recognize all reported isoforms (NP_001387.2; NP_569120.1; NP_567824.1; NP_569122.1). This antibody is not expected to cross-react with DYRK1B. |
| Immunogen Sequence: |
PHSHQYSDRRQPN |
| Post Translational Modifications | Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro). |
| Function | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Plays an important role in double-strand breaks (DSBs) repair following DNA damage. Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits p53/TP53 activity and apoptosis. Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434'. |
| Protein Name | Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1aDual Specificity Yak1-Related KinaseHp86Protein Kinase Minibrain HomologMnbhHmnb |
| Database Links | Reactome: R-HSA-1538133 |
| Cellular Localisation | NucleusNucleus Speckle |
| Alternative Antibody Names | Anti-Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1a antibodyAnti-Dual Specificity Yak1-Related Kinase antibodyAnti-Hp86 antibodyAnti-Protein Kinase Minibrain Homolog antibodyAnti-Mnbh antibodyAnti-Hmnb antibodyAnti-DYRK1A antibodyAnti-DYRK antibodyAnti-MNB antibodyAnti-MNBH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
