| Host: |
Rabbit |
| Applications: |
ELISA/IHC/IP/WB |
| Reactivity: |
Human/Monkey/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DYRK1A (300-350) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.5 µg/µl |
| Dilution Range: |
WB: 1:500ELISA: 1:10, 000IP: 1:150IHC: 1:50-1:150 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
DYRK1A |
| Gene ID: |
1859 |
| Uniprot ID: |
DYR1A_HUMAN |
| Immunogen Region: |
300-350 |
| Immunogen: |
Synthetic peptide taken within amino acid region 300-350 on human Dual specificity tyrosine-phosphorylation-regulated kinase 1A. |
| Tissue Specificity | Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney. |
| Post Translational Modifications | Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro). |
| Function | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Plays an important role in double-strand breaks (DSBs) repair following DNA damage. Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits p53/TP53 activity and apoptosis. Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434'. |
| Protein Name | Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1aDual Specificity Yak1-Related KinaseHp86Protein Kinase Minibrain HomologMnbhHmnb |
| Database Links | Reactome: R-HSA-1538133 |
| Cellular Localisation | NucleusNucleus Speckle |
| Alternative Antibody Names | Anti-Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1a antibodyAnti-Dual Specificity Yak1-Related Kinase antibodyAnti-Hp86 antibodyAnti-Protein Kinase Minibrain Homolog antibodyAnti-Mnbh antibodyAnti-Hmnb antibodyAnti-DYRK1A antibodyAnti-DYRK antibodyAnti-MNB antibodyAnti-MNBH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
