| Function | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC). |
| Protein Name | Cytoplasmic Dynein 1 Light Intermediate Chain 1Lic1Dynein Light Chain ADlc-ADynein Light Intermediate Chain 1 - CytosolicDlic-1 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2132295Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-3371497Reactome: R-HSA-5663220Reactome: R-HSA-6798695Reactome: R-HSA-6807878Reactome: R-HSA-6811436Reactome: R-HSA-68877Reactome: R-HSA-9609690Reactome: R-HSA-9646399Reactome: R-HSA-9648025 |
| Cellular Localisation | CytoplasmChromosomeCentromereKinetochoreCytoskeletonSpindle PoleRecycling Endosome MembraneDuring InterphaseLocalized In Vesicles Continuously Moving From Peripheral Sorting Endosomes In The Cell Towards The Pericentrosomal Endosomal Recycling Compartment (Erc) |
| Alternative Antibody Names | Anti-Cytoplasmic Dynein 1 Light Intermediate Chain 1 antibodyAnti-Lic1 antibodyAnti-Dynein Light Chain A antibodyAnti-Dlc-A antibodyAnti-Dynein Light Intermediate Chain 1 - Cytosolic antibodyAnti-Dlic-1 antibodyAnti-DYNC1LI1 antibodyAnti-DNCLI1 antibody |
Information sourced from Uniprot.org
