| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000IHC-P:1:20-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DYNC1I1 |
| Gene ID: | 1780 |
| Uniprot ID: | DC1I1_HUMAN |
| Immunogen Region: | 1-220 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human DYNC1I1 (NP_001129028.1). |
| Immunogen Sequence: | MSDKSDLKAELERKKQRLAQ IREEKKRKEEERKKKEADMQ QKKEPVQDDSDLDRKRRETE ALLQSIGISPEPPLVPTPMS PSSKSVSTPSEAGSQDSGDL GPLTRTLQWDTDPSVLQLQS DSELGRRLHKLGVSKVTQVD FLPREVVSYSKETQTPLATH QSEEDEEDEEMVESKVGQDS ELENQDKKQEVKEAPPRELT EEEKQQILHSEEFLIFFDRT |
| Function | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores. |
| Protein Name | Cytoplasmic Dynein 1 Intermediate Chain 1Cytoplasmic Dynein Intermediate Chain 1Dynein Intermediate Chain 1 - CytosolicDh Ic-1 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2132295Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-3371497Reactome: R-HSA-5663220Reactome: R-HSA-6807878Reactome: R-HSA-6811436Reactome: R-HSA-68877Reactome: R-HSA-9609690Reactome: R-HSA-9646399Reactome: R-HSA-9648025 |
| Cellular Localisation | CytoplasmChromosomeCentromereKinetochoreCytoskeletonSpindle Pole |
| Alternative Antibody Names | Anti-Cytoplasmic Dynein 1 Intermediate Chain 1 antibodyAnti-Cytoplasmic Dynein Intermediate Chain 1 antibodyAnti-Dynein Intermediate Chain 1 - Cytosolic antibodyAnti-Dh Ic-1 antibodyAnti-DYNC1I1 antibodyAnti-DNCI1 antibodyAnti-DNCIC1 antibody |
Information sourced from Uniprot.org
