Anti-DVL1 antibody (STJ192994)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Segment polarity protein dishevelled homolog DVL-1 for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DVL1 |
| Gene ID | 1855 |
| Uniprot ID | DVL1_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | DVL1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). |
| Protein Name | Segment Polarity Protein Dishevelled Homolog Dvl-1Dishevelled-1Dsh Homolog 1 |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-201688Reactome: R-HSA-4086400Reactome: R-HSA-4641258Reactome: R-HSA-4641262Reactome: R-HSA-5368598Reactome: R-HSA-5663220Reactome: R-HSA-9673324 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytosolCytoplasmic VesicleLocalizes At The Cell Membrane Upon Interaction With Frizzled Family Members |
| Alternative Antibody Names | Anti-Segment Polarity Protein Dishevelled Homolog Dvl-1 antibodyAnti-Dishevelled-1 antibodyAnti-Dsh Homolog 1 antibodyAnti-DVL1 antibody |
Information sourced from Uniprot.org