| Short Description : | Rabbit polyclonal DUSP16 (416-665) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:6000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DUSP16 |
| Gene ID: | 80824 |
| Uniprot ID: | DUS16_HUMAN |
| Immunogen Region: | 416-665 |
| Immunogen Sequence: | SLHGFSSSEDALEYYKPSTT LDGTNKLCQFSPVQELSEQT PETSPDKEEASIPKKLQTAR PSDSQSKRLHSVRTSSSGTA QRSLLSPLHRSGSVEDNYHT SFLFGLSTSQQHLTKSAGLG LKGWHSDILAPQTSTPSLTS SWYFATESSHFYSASAIYGG SASYSAYSCSQLPTCGDQVY SVRRRQKPSDRADSRRSWHE ESPFEKQFKRRSCQMEFGES IMSENRSREELGKVGSQSS |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 416-665 of human DUSP16 (NP_085143.1). |
| Post Translational Modifications | Phosphorylated at Ser-446 by MAPK1/ERK2, which prevents its degradation, and thereby stabilizes it and blocks JNK MAPK activity. (Microbial infection) Acetylated at Lys-55 by the M.tuberculosis Eis protein.this leads to the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS (reactive oxygen species) generation for enhanced intracellular survival of M.tuberculosis. |
| Function | Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. |
| Protein Name | Dual Specificity Protein Phosphatase 16Mitogen-Activated Protein Kinase Phosphatase 7Map Kinase Phosphatase 7Mkp-7 |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-5675221Reactome: R-HSA-9636569Reactome: R-HSA-9652817 |
| Cellular Localisation | CytoplasmNucleusCytoplasmic VesicleAfter Dissociation Upon Agtr StimulationRe-Associates With Arrb2 On Endocytic Vesicles |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 16 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase 7 antibodyAnti-Map Kinase Phosphatase 7 antibodyAnti-Mkp-7 antibodyAnti-DUSP16 antibodyAnti-KIAA1700 antibodyAnti-MKP7 antibody |
Information sourced from Uniprot.org
