Anti-DUOX1 antibody (972-985) (STJ72649)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-DUOX1 (972-985) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 170kDa band observed in Human Testis lysates (calculated MW of 177kDa according to NP_059130.2). Recommended concentration: 0.1-0.3µg/ml. Primary incubation was 1 hour. An addi |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | DUOX1 |
| Gene ID | 53905 |
| Uniprot ID | DUOX1_HUMAN |
| Accession Number | NP_059130.2 |
| Immunogen Region | 972-985 |
| Immunogen Sequence | CSRSDIETELTPQR |
| Specificity | Reported variants represent identical protein: NP_787954.1, NP_059130.2. This antibody is not expected to cross-react with DUOX2. |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. |
| Protein Name | Dual Oxidase 1Large Nox 1Long Nox 1Nadph Thyroid Oxidase 1Thyroid Oxidase 1 |
| Database Links | Reactome: R-HSA-209968 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinLocalizes To The Apical Membrane Of Epithelial Cells |
| Alternative Antibody Names | Anti-Dual Oxidase 1 antibodyAnti-Large Nox 1 antibodyAnti-Long Nox 1 antibodyAnti-Nadph Thyroid Oxidase 1 antibodyAnti-Thyroid Oxidase 1 antibodyAnti-DUOX1 antibodyAnti-DUOX antibodyAnti-LNOX1 antibodyAnti-THOX1 antibody |
Information sourced from Uniprot.org