| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase DTX1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DTX1 |
| Gene ID: |
1840 |
| Uniprot ID: |
DTX1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of DTX1 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human DTX1 |
| Post Translational Modifications | Ubiquitinated.undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH. |
| Function | Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. |
| Protein Name | E3 Ubiquitin-Protein Ligase Dtx1Protein Deltex-1Deltex1Hdtx1Ring-Type E3 Ubiquitin Transferase Dtx1 |
| Database Links | Reactome: R-HSA-2122948 |
| Cellular Localisation | CytoplasmNucleusPredominantly CytoplasmicAssociates With Endocytic VesiclesPartially Nuclear |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Dtx1 antibodyAnti-Protein Deltex-1 antibodyAnti-Deltex1 antibodyAnti-Hdtx1 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Dtx1 antibodyAnti-DTX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
