Anti-DTNB antibody (STJA0008972)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human DTNB
General Information
| Short Description | Rabbit polyclonal anti-Dystrobrevin beta for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DTNB |
| Gene ID | 1838 |
| Uniprot ID | DTNB_HUMAN |
| Immunogen | Synthesized peptide derived from human DTNB |
| Specificity | This antibody detects endogenous levels of DTNB at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Phosphorylated by PKA. Phosphorylation at Thr-11 alters the interaction with KIF5A. |
| Function | Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids. May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation. May be required for proper maturation and function of a subset of inhibitory synapses. |
| Protein Name | Dystrobrevin BetaDtn-BBeta-Dystrobrevin |
| Database Links | Reactome: R-HSA-9913351 |
| Cellular Localisation | CytoplasmPostsynaptic DensityCell ProjectionDendriteBasal Cell MembranePostsynapseNucleusLocalized At Inhibitory Synapses On The Dendrites Of Cerebellar Purkinje Cells |
| Alternative Antibody Names | Anti-Dystrobrevin Beta antibodyAnti-Dtn-B antibodyAnti-Beta-Dystrobrevin antibodyAnti-DTNB antibody |
Information sourced from Uniprot.org