| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DTNA (240-480) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DTNA |
| Gene ID: |
1837 |
| Uniprot ID: |
DTNA_HUMAN |
| Immunogen Region: |
240-480 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 240-480 of human DTNA (NP_001381.2). |
| Immunogen Sequence: |
PVECSYCHSESMMGFRYRCQ QCHNYQLCQDCFWRGHAGGS HSNQHQMKEYTSWKSPAKKL TNALSKSLSCASSREPLHPM FPDQPEKPLNLAHIVDTWPP RPVTSMNDTLFSHSVPSSGS PFITRSSPPKDSEVEQNKLL ARAAPAFLKGKGIQYSLNVA DRLADEHVLIGLYVNMLRNN PSCMLESSNRLDEEHRLIAR YAARLAAESSSSQPPQQRSA PDISFTIDANKQQRQLIAE |
| Tissue Specificity | Highly expressed in brain, skeletal and cardiac muscles, and expressed at lower levels in lung, liver and pancreas. Isoform 2 is not expressed in cardiac muscle. Isoform 7 and isoform 8 are only expressed in muscle. |
| Post Translational Modifications | Phosphorylation of DTN-1 on tyrosine kinase substrate domain present in the C-terminus. |
| Function | May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. |
| Protein Name | Dystrobrevin AlphaDtn-AAlpha-DystrobrevinDystrophin-Related Protein 3 |
| Cellular Localisation | CytoplasmSynapseCell MembraneIn Peripheral NervesColocalizes With Magee1 In The Schwann Cell Membrane |
| Alternative Antibody Names | Anti-Dystrobrevin Alpha antibodyAnti-Dtn-A antibodyAnti-Alpha-Dystrobrevin antibodyAnti-Dystrophin-Related Protein 3 antibodyAnti-DTNA antibodyAnti-DRP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
