| Host: |
Goat |
| Applications: |
Pep-ELISA/ICC |
| Reactivity: |
Human/Mouse/Dog/Cow/Pig |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-DSS1/SHFM1 (C-Term) is suitable for use in ELISA and Immunocytochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
SEM1 |
| Gene ID: |
7979 |
| Uniprot ID: |
SEM1_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_006295.1 |
| Immunogen Sequence: |
RAELEKHGYKMETS |
| Function | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells. |
| Protein Name | 26s Proteasome Complex Subunit Sem126s Proteasome Complex Subunit Dss1Deleted In Split Hand/Split Foot Protein 1Split Hand/Foot Deleted Protein 1Split Hand/Foot Malformation Type 1 Protein |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-1234176Reactome: R-HSA-1236974Reactome: R-HSA-1236978Reactome: R-HSA-174084Reactome: R-HSA-174113Reactome: R-HSA-174154Reactome: R-HSA-174178Reactome: R-HSA-174184Reactome: R-HSA-180534Reactome: R-HSA-180585Reactome: R-HSA-187577Reactome: R-HSA-195253Reactome: R-HSA-202424Reactome: R-HSA-211733Reactome: R-HSA-2467813Reactome: R-HSA-2871837Reactome: R-HSA-349425Reactome: R-HSA-350562Reactome: R-HSA-382556Reactome: R-HSA-450408Reactome: R-HSA-4608870Reactome: R-HSA-4641257Reactome: R-HSA-4641258Reactome: R-HSA-5358346Reactome: R-HSA-5362768Reactome: R-HSA-5607761Reactome: R-HSA-5607764Reactome: R-HSA-5610780Reactome: R-HSA-5610783Reactome: R-HSA-5610785Reactome: R-HSA-5632684Reactome: R-HSA-5658442Reactome: R-HSA-5668541Reactome: R-HSA-5676590Reactome: R-HSA-5678895Reactome: R-HSA-5685942Reactome: R-HSA-5687128Reactome: R-HSA-5689603Reactome: R-HSA-5689880Reactome: R-HSA-5693554Reactome: R-HSA-5693568Reactome: R-HSA-5693579Reactome: R-HSA-5693616Reactome: R-HSA-68867Reactome: R-HSA-68949Reactome: R-HSA-69017Reactome: R-HSA-69481Reactome: R-HSA-69601Reactome: R-HSA-75815Reactome: R-HSA-8852276Reactome: R-HSA-8854050Reactome: R-HSA-8939236Reactome: R-HSA-8939902Reactome: R-HSA-8941858Reactome: R-HSA-8948751Reactome: R-HSA-8951664Reactome: R-HSA-9010553Reactome: R-HSA-9020702Reactome: R-HSA-9604323Reactome: R-HSA-9701192Reactome: R-HSA-9704331Reactome: R-HSA-9704646Reactome: R-HSA-9709275Reactome: R-HSA-9709570Reactome: R-HSA-9755511Reactome: R-HSA-9762114Reactome: R-HSA-9763198Reactome: R-HSA-9824272Reactome: R-HSA-983168 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-26s Proteasome Complex Subunit Sem1 antibodyAnti-26s Proteasome Complex Subunit Dss1 antibodyAnti-Deleted In Split Hand/Split Foot Protein 1 antibodyAnti-Split Hand/Foot Deleted Protein 1 antibodyAnti-Split Hand/Foot Malformation Type 1 Protein antibodyAnti-SEM1 antibodyAnti-C7orf76 antibodyAnti-DSS1 antibodyAnti-SHFDG1 antibodyAnti-SHFM1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
