Anti-DSG1 antibody (800-1049) (STJ111854)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DSG1 (800-1049) antibody for use in WB, IF, ICC and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DSG1 |
| Gene ID | 1828 |
| Uniprot ID | DSG1_HUMAN |
| Immunogen Region | 800-1049 |
| Immunogen Sequence | SPHFGTTTVISESTYPSGPG VLHPKPILDPLGYGNVTVTE SYTTSDTLKPSVHVHDNRPA SNVVVTERVVGPISGADLHG MLEMPDLRDGSNVIVTERVI APSSSLPTSLTIHHPRESSN VVVTERVIQPTSGMIGSLSM HPELANAHNVIVTERVVSGA GVTGISGTTGISGGIGSSGL VGTSMGAGSGALSGAGISGG GIGLSSLGGTASIGHMRSSS DHHFNQTIGSASPSTARSR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 800-1049 of human DSG1 (NP_001933.2). |
Additional Info
| Tissue Specificity | Expressed in all suprabasal layers of the epidermis, with the highest expression seen in the granular layer (at protein level). |
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
| Protein Name | Desmoglein-1Cadherin Family Member 4Desmosomal Glycoprotein 1Dg1DgiPemphigus Foliaceus Antigen |
| Database Links | Reactome: R-HSA-351906Reactome: R-HSA-6798695Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-9696264Reactome: R-HSA-9696270 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionDesmosomeCytoplasmNucleus |
| Alternative Antibody Names | Anti-Desmoglein-1 antibodyAnti-Cadherin Family Member 4 antibodyAnti-Desmosomal Glycoprotein 1 antibodyAnti-Dg1 antibodyAnti-Dgi antibodyAnti-Pemphigus Foliaceus Antigen antibodyAnti-DSG1 antibodyAnti-CDHF4 antibody |
Information sourced from Uniprot.org