Anti-DSC2 antibody (520-690) (STJ112249)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DSC2 (520-690) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DSC2 |
| Gene ID | 1824 |
| Uniprot ID | DSC2_HUMAN |
| Immunogen Region | 520-690 |
| Immunogen Sequence | IDENTGSIKVFRSLDREAET IKNGIYNITVLASDQGGRTC TGTLGIILQDVNDNSPFIPK KTVIICKPTMSSAEIVAVDP DEPIHGPPFDFSLESSTSEV QRMWRLKAINDTAARLSYQN DPPFGSYVVPITVRDRLGMS SVTSLDVTLCDCITENDCTH RVDPRIGGGGV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 520-690 of human DSC2 (NP_077740.1). |
Additional Info
| Tissue Specificity | Expressed at intercalated disks in the heart, where it is colocalized with CDH2 (at protein level). Expressed in intestinal mucosal cells (at protein level). |
| Function | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation. Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function. Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration. |
| Protein Name | Desmocollin-2Cadherin Family Member 2Desmocollin-3Desmosomal Glycoprotein IiDesmosomal Glycoprotein Iii |
| Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionDesmosome |
| Alternative Antibody Names | Anti-Desmocollin-2 antibodyAnti-Cadherin Family Member 2 antibodyAnti-Desmocollin-3 antibodyAnti-Desmosomal Glycoprotein Ii antibodyAnti-Desmosomal Glycoprotein Iii antibodyAnti-DSC2 antibodyAnti-CDHF2 antibodyAnti-DSC3 antibody |
Information sourced from Uniprot.org