Anti-DSC1 antibody (824-894) [S5164RM] (STJ11105164)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Desmocollin-1 (824-894) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5164RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DSC1 |
| Gene ID | 1823 |
| Uniprot ID | DSC1_HUMAN |
| Immunogen Region | 824-894 |
| Immunogen Sequence | QPRLGEKVYLCGQDEEHKHC EDYVCSYNYEGKGSLAGSVG CCSDRQEEEGLEFLDHLEPK FRTLAKTCIKK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 824-894 of human Desmocollin 1 (NP_077739.1). |
Additional Info
| Tissue Specificity | Strongly expressed in epidermis, less in lymph node and tongue. |
| Function | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Required for desmosome adhesion strength between the granular layers of the epidermis, as a result moderates epidermal proliferation and differentiation. Is therefore required to maintain postnatal epidermal barrier function and normal hair follicle morphology into adulthood. |
| Protein Name | Desmocollin-1Cadherin Family Member 1Desmosomal Glycoprotein 2/3Dg2/Dg3 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionDesmosome |
| Alternative Antibody Names | Anti-Desmocollin-1 antibodyAnti-Cadherin Family Member 1 antibodyAnti-Desmosomal Glycoprotein 2/3 antibodyAnti-Dg2/Dg3 antibodyAnti-DSC1 antibodyAnti-CDHF1 antibody |
Information sourced from Uniprot.org