Anti-Drebrin antibody [DBN-N-03] (STJ16103136)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2b
ImmunogenBacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)
General Information
| Short Description | Mouse monoclonal anti-Drebrin for use in FC, WB and MC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/WB/MC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | DBN-N-03 |
| Isotype | IgG2b |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by protein-A affinity chromatography. |
| Formulation | Tris buffered saline (TBS) , pH 8.0, 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | DBN1 |
| Gene ID | 1627 |
| Uniprot ID | DREB_HUMAN |
| Immunogen | Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326) |
Additional Info
| Function | Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections. Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS. Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines. Involved in memory-related synaptic plasticity in the hippocampus. |
| Protein Name | DrebrinDevelopmentally-Regulated Brain Protein |
| Database Links | Reactome: R-HSA-9013405Reactome: R-HSA-9013407Reactome: R-HSA-9013418Reactome: R-HSA-9013422 |
| Cellular Localisation | CytoplasmCell ProjectionDendriteCell CortexCell JunctionGrowth ConeIn The Absence Of AntigenEvenly Distributed Throughout Subcortical Regions Of The T-Cell Membrane And CytoplasmIn The Presence Of AntigenDistributes To The Immunological Synapse Forming At The T-Cell-Apc Contact AreaWhere It Localizes At The Peripheral And Distal Supramolecular Activation Clusters (Smac)Colocalized With Rufy3 And F-Actin At The Transitional Domain Of The Axonal Growth Cone |
| Alternative Antibody Names | Anti-Drebrin antibodyAnti-Developmentally-Regulated Brain Protein antibodyAnti-DBN1 antibodyAnti-D0S117E antibody |
Information sourced from Uniprot.org