Anti-Draxin antibody (N-Term) (STJ13101040)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the n-terminal region of mouse Dorsal repulsive axon guidance protein (Draxin, Neucrin) conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-Draxin (N-Term) for use in IHC and WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Draxin |
| Gene ID | 70433 |
| Uniprot ID | DRAXI_MOUSE |
| Immunogen | A synthetic peptide from the n-terminal region of mouse Dorsal repulsive axon guidance protein (Draxin, Neucrin) conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | N-Term |
| Specificity | Specific for Draxin. |
Additional Info
| Function | Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. |
| Protein Name | DraxinDorsal Inhibitory Axon Guidance ProteinDorsal Repulsive Axon Guidance ProteinNeucrin |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Draxin antibodyAnti-Dorsal Inhibitory Axon Guidance Protein antibodyAnti-Dorsal Repulsive Axon Guidance Protein antibodyAnti-Neucrin antibodyAnti-Draxin antibody |
Information sourced from Uniprot.org