| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Protein Dr1 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DR1 |
| Gene ID: | 1810 |
| Uniprot ID: | NC2B_HUMAN |
| Specificity: | This antibody detects endogenous levels of DR1 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human DR1 |
| Function | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. |
| Protein Name | Protein Dr1Down-Regulator Of Transcription 1Negative Cofactor 2-BetaNc2-BetaTata-Binding Protein-Associated Phosphoprotein |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Protein Dr1 antibodyAnti-Down-Regulator Of Transcription 1 antibodyAnti-Negative Cofactor 2-Beta antibodyAnti-Nc2-Beta antibodyAnti-Tata-Binding Protein-Associated Phosphoprotein antibodyAnti-DR1 antibody |
Information sourced from Uniprot.org