Anti-DR1 antibody (1-176) (STJ28983)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DR1 (1-176) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DR1 |
| Gene ID | 1810 |
| Uniprot ID | NC2B_HUMAN |
| Immunogen Region | 1-176 |
| Immunogen Sequence | MASSSGNDDDLTIPRAAINK MIKETLPNVRVANDARELVV NCCTEFIHLISSEANEICNK SEKKTISPEHVIQALESLGF GSYISEVKEVLQECKTVALK RRKASSRLENLGIPEEELLR QQQELFAKARQQQAELAQQE WLQMQQAAQQAQLAAASASA SNQAGSSQDEEDDDDI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-176 of human DR1 (NP_001929.1). |
Additional Info
| Post Translational Modifications | Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1. |
| Function | The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. |
| Protein Name | Protein Dr1Down-Regulator Of Transcription 1Negative Cofactor 2-BetaNc2-BetaTata-Binding Protein-Associated Phosphoprotein |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Protein Dr1 antibodyAnti-Down-Regulator Of Transcription 1 antibodyAnti-Negative Cofactor 2-Beta antibodyAnti-Nc2-Beta antibodyAnti-Tata-Binding Protein-Associated Phosphoprotein antibodyAnti-DR1 antibody |
Information sourced from Uniprot.org