Anti-DPYSL2 antibody (480-529 aa) (STJ92480)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human DRP-2 at the amino acid range 480-529
General Information
| Short Description | Rabbit polyclonal anti-Dihydropyrimidinase-related protein 2 (480-529 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DPYSL2 |
| Gene ID | 1808 |
| Uniprot ID | DPYL2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human DRP-2 at the amino acid range 480-529 |
| Immunogen Region | 480-529 aa |
| Specificity | CRMP-2 Polyclonal Antibody detects endogenous levels of CRMP-2 protein. |
Additional Info
| Post Translational Modifications | 3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509. Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration. Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B. |
| Function | Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. |
| Protein Name | Dihydropyrimidinase-Related Protein 2Drp-2Collapsin Response Mediator Protein 2Crmp-2N2a3Unc-33-Like Phosphoprotein 2Ulip-2 |
| Database Links | Reactome: R-HSA-399956Reactome: R-HSA-437239 |
| Cellular Localisation | CytoplasmCytosolCytoskeletonMembraneTightly But Non-Covalently Associated With Membranes |
| Alternative Antibody Names | Anti-Dihydropyrimidinase-Related Protein 2 antibodyAnti-Drp-2 antibodyAnti-Collapsin Response Mediator Protein 2 antibodyAnti-Crmp-2 antibodyAnti-N2a3 antibodyAnti-Unc-33-Like Phosphoprotein 2 antibodyAnti-Ulip-2 antibodyAnti-DPYSL2 antibodyAnti-CRMP2 antibodyAnti-ULIP2 antibody |
Information sourced from Uniprot.org