Anti-DPP8 antibody (STJA0009177)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human DPP8
General Information
| Short Description | Rabbit polyclonal anti-Dipeptidyl peptidase 8 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DPP8 |
| Gene ID | 54878 |
| Uniprot ID | DPP8_HUMAN |
| Immunogen | Synthesized peptide derived from human DPP8 |
| Specificity | This antibody detects endogenous levels of DPP8 at Human, Mouse |
Additional Info
| Function | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8. Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation. The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8.however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition. |
| Protein Name | Dipeptidyl Peptidase 8Dp8Dipeptidyl Peptidase Iv-Related Protein 1Dprp-1Dipeptidyl Peptidase ViiiDpp ViiiProlyl Dipeptidase Dpp8 |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dipeptidyl Peptidase 8 antibodyAnti-Dp8 antibodyAnti-Dipeptidyl Peptidase Iv-Related Protein 1 antibodyAnti-Dprp-1 antibodyAnti-Dipeptidyl Peptidase Viii antibodyAnti-Dpp Viii antibodyAnti-Prolyl Dipeptidase Dpp8 antibodyAnti-DPP8 antibodyAnti-DPRP1 antibodyAnti-MSTP097 antibodyAnti-MSTP135 antibodyAnti-MSTP141 antibody |
Information sourced from Uniprot.org