| Short Description : | Rabbit polyclonal DPEP1 (17-385) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DPEP1 |
| Gene ID: | 1800 |
| Uniprot ID: | DPEP1_HUMAN |
| Immunogen Region: | 17-385 |
| Immunogen Sequence: | DFFRDEAERIMRDSPVIDGH NDLPWQLLDMFNNRLQDERA NLTTLAGTHTNIPKLRAGFV GGQFWSVYTPCDTQNKDAVR RTLEQMDVVHRMCRMYPETF LYVTSSAGIRQAFREGKVAS LIGVEGGHSIDSSLGVLRAL YQLGMRYLTLTHSCNTPWAD NWLVDTGDSEPQSQGLSPFG QRVVKELNRLGVLIDLAHVS VATMKATLQLSRAPVIFSHS SAYSVCASRRNVPDDVLRL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-385 of human DPEP1 (NP_001121613.1). |
| Tissue Specificity | Expressed in lung and kidneys. |
| Function | Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4. Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation. Also possesses beta lactamase activity and can hydrolyze the beta-lactam antibiotic imipenem. Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver. |
| Protein Name | Dipeptidase 1Beta-LactamaseDehydropeptidase-IMicrosomal DipeptidaseRenal DipeptidaseHrdp |
| Database Links | Reactome: R-HSA-2142691Reactome: R-HSA-5423646Reactome: R-HSA-9664535 |
| Cellular Localisation | Apical Cell MembraneLipid-AnchorGpi-AnchorCell ProjectionMicrovillus MembraneBrush Border Membrane |
| Alternative Antibody Names | Anti-Dipeptidase 1 antibodyAnti-Beta-Lactamase antibodyAnti-Dehydropeptidase-I antibodyAnti-Microsomal Dipeptidase antibodyAnti-Renal Dipeptidase antibodyAnti-Hrdp antibodyAnti-DPEP1 antibodyAnti-MDP antibodyAnti-RDP antibody |
Information sourced from Uniprot.org
