Anti-DORFIN/RNF19 antibody (C-Term) (STJ70266)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-DORFIN/RNF19 (C-Term) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: No signal obtained yet but low background observed in Human Skeletal Muscle, Human Kidney, Human Liver, Human Heart and Human Brain lysates at up to 2µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | RNF19A |
| Gene ID | 25897 |
| Uniprot ID | RN19A_HUMAN |
| Accession Number | NP_056250.3; NP_904355.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | QTMELKVAIQTEI |
| Specificity | Both variants (NP_056250.3; NP_904355.1) encode the same protein. |
Additional Info
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf19aDouble Ring-Finger ProteinDorfinRing Finger Protein 19aP38 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomePresent In The Hyaline Inclusion Bodies Specifically Found In Motor Neurons From Amyotrophic Lateral Sclerosis PatientsPresent In The Lewy Bodies Specifically Found In Neurons From Parkinson Disease Patients |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf19a antibodyAnti-Double Ring-Finger Protein antibodyAnti-Dorfin antibodyAnti-Ring Finger Protein 19a antibodyAnti-P38 antibodyAnti-RNF19A antibodyAnti-RNF19 antibody |
Information sourced from Uniprot.org