| Short Description : | Rabbit polyclonal anti-Docking protein 4 (11-60 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DOK4 |
| Gene ID: | 55715 |
| Uniprot ID: | DOK4_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human DOK4 at the amino acid range 11-60 |
| Immunogen Region: | 11-60 aa |
| Specificity: | Dok-4 Polyclonal Antibody detects endogenous levels of Dok-4 protein. |
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation. |
| Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. |
| Protein Name | Docking Protein 4Downstream Of Tyrosine Kinase 4Insulin Receptor Substrate 5Irs-5Irs5 |
| Database Links | Reactome: R-HSA-8853659 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Docking Protein 4 antibodyAnti-Downstream Of Tyrosine Kinase 4 antibodyAnti-Insulin Receptor Substrate 5 antibodyAnti-Irs-5 antibodyAnti-Irs5 antibodyAnti-DOK4 antibody |
Information sourced from Uniprot.org
