Anti-DOCK7 antibody (STJ190740)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Dedicator of cytokinesis protein 7 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DOCK7 |
| Gene ID | 85440 |
| Uniprot ID | DOCK7_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | DOCK7 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation.negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3. |
| Protein Name | Dedicator Of Cytokinesis Protein 7 |
| Database Links | Reactome: R-HSA-8875555Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-983231 |
| Cellular Localisation | Cell ProjectionAxonEnriched In The Developing Axons Of Hippocampal Neurons |
| Alternative Antibody Names | Anti-Dedicator Of Cytokinesis Protein 7 antibodyAnti-DOCK7 antibodyAnti-KIAA1771 antibody |
Information sourced from Uniprot.org