Anti-DOCK3 antibody (STJA0007771)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	DOCK3
Gene ID:	1795
Uniprot ID:	DOCK3_HUMAN
Specificity:	This antibody detects endogenous levels of DOCK3; MOCA at Human
Immunogen:	Synthesized peptide derived from human DOCK3; MOCA

Function	Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors.
Protein Name	Dedicator Of Cytokinesis Protein 3 Modifier Of Cell Adhesion Presenilin-Binding Protein Pbp
Database Links	Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013408 Reactome: R-HSA-9032759 Reactome: R-HSA-983231
Cellular Localisation	Cytoplasm
Alternative Antibody Names	Anti-Dedicator Of Cytokinesis Protein 3 antibody Anti-Modifier Of Cell Adhesion antibody Anti-Presenilin-Binding Protein antibody Anti-Pbp antibody Anti-DOCK3 antibody Anti-KIAA0299 antibody Anti-MOCA antibody

Information sourced from Uniprot.org

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