Anti-DOCK10 antibody (2051-2101 aa) (STJ194052)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human DOC10 at the amino acid range 2051-2101
General Information
| Short Description | Rabbit polyclonal anti-Dedicator of cytokinesis protein 10 (2051-2101 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DOCK10 |
| Gene ID | 55619 |
| Uniprot ID | DOC10_HUMAN |
| Immunogen | Synthesized peptide derived from the human DOC10 at the amino acid range 2051-2101 |
| Immunogen Region | 2051-2101 aa |
| Specificity | This antibody detects endogenous levels of DOC10 at Human/Mouse |
Additional Info
| Function | Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. |
| Protein Name | Dedicator Of Cytokinesis Protein 10Zizimin-3 |
| Database Links | Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013423Reactome: R-HSA-983231 |
| Cellular Localisation | NucleusCytoplasmCell ProjectionDendritic Spine |
| Alternative Antibody Names | Anti-Dedicator Of Cytokinesis Protein 10 antibodyAnti-Zizimin-3 antibodyAnti-DOCK10 antibodyAnti-KIAA0694 antibodyAnti-ZIZ3 antibody |
Information sourced from Uniprot.org