Anti-DOCK1 antibody (C-Term) (STJ70065)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-DOCK1 (C-Term) is suitable for use in Western Blot research applications. |
| Applications | WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | WB: Approx 150-200kDa band seen in A431 cell lysate. Recommended for use at 3-4µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | DOCK1 |
| Gene ID | 1793 |
| Uniprot ID | DOCK1_HUMAN |
| Accession Number | NP_001371.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | TTRKQTSVDSGIVQ |
Additional Info
| Function | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. |
| Protein Name | Dedicator Of Cytokinesis Protein 1180 Kda Protein Downstream Of CrkDock180 |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-418885Reactome: R-HSA-4420097Reactome: R-HSA-8849471Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-9664422Reactome: R-HSA-983231 |
| Cellular Localisation | CytoplasmMembraneRecruited To Membranes Via Its Interaction With Phosphatidylinositol 345-Trisphosphate |
| Alternative Antibody Names | Anti-Dedicator Of Cytokinesis Protein 1 antibodyAnti-180 Kda Protein Downstream Of Crk antibodyAnti-Dock180 antibodyAnti-DOCK1 antibody |
Information sourced from Uniprot.org