• STJ70065 staining (4µg/ml) of A431 lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.

Anti-DOCK1 antibody (C-Term) (STJ70065)

SKU:
STJ70065-100

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Host: Goat
Applications: WB
Reactivity: Human/Mouse/Rat/Dog/Pig/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-DOCK1 (C-Term) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-Recommended for use at 3-4µg/ml
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: DOCK1
Gene ID: 1793
Uniprot ID: DOCK1_HUMAN
Immunogen Region: C-Term
Accession Number: NP_001371.1
Immunogen Sequence: TTRKQTSVDSGIVQ
Function Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.
Protein Name Dedicator Of Cytokinesis Protein 1
180 Kda Protein Downstream Of Crk
Dock180
Database Links Reactome: R-HSA-2029482
Reactome: R-HSA-418885
Reactome: R-HSA-4420097
Reactome: R-HSA-8849471
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013408
Reactome: R-HSA-9664422
Reactome: R-HSA-983231
Cellular Localisation Cytoplasm
Membrane
Recruited To Membranes Via Its Interaction With Phosphatidylinositol 3
4
5-Trisphosphate
Alternative Antibody Names Anti-Dedicator Of Cytokinesis Protein 1 antibody
Anti-180 Kda Protein Downstream Of Crk antibody
Anti-Dock180 antibody
Anti-DOCK1 antibody

Information sourced from Uniprot.org

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