• Western blot analysis of lysates from HeLa cells, using DOCK1 Antibody. The lane on the right is blocked with the synthesized peptide.

Anti-DOCK1 antibody (1661-1710 aa) (STJ92756)

SKU:
STJ92756

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Dedicator of cytokinesis protein 1 (1661-1710 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:40000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DOCK1
Gene ID: 1793
Uniprot ID: DOCK1_HUMAN
Immunogen Region: 1661-1710 aa
Specificity: DOCK 180 Polyclonal Antibody detects endogenous levels of DOCK 180 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human DOCK1 at the amino acid range 1661-1710
Function Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.
Protein Name Dedicator Of Cytokinesis Protein 1
180 Kda Protein Downstream Of Crk
Dock180
Database Links Reactome: R-HSA-2029482
Reactome: R-HSA-418885
Reactome: R-HSA-4420097
Reactome: R-HSA-8849471
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013408
Reactome: R-HSA-9664422
Reactome: R-HSA-983231
Cellular Localisation Cytoplasm
Membrane
Recruited To Membranes Via Its Interaction With Phosphatidylinositol 3
4
5-Trisphosphate
Alternative Antibody Names Anti-Dedicator Of Cytokinesis Protein 1 antibody
Anti-180 Kda Protein Downstream Of Crk antibody
Anti-Dock180 antibody
Anti-DOCK1 antibody

Information sourced from Uniprot.org

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