Anti-DOC2b antibody (Internal Region) (STJ13101037)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the internal region of mouse DOC2b (Double C2-like domain-containing protein beta) conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-DOC2b (Internal Region) for use in IHC and WB in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Doc2b |
| Gene ID | 13447 |
| Uniprot ID | DOC2B_MOUSE |
| Immunogen | A synthetic peptide from the internal region of mouse DOC2b (Double C2-like domain-containing protein beta) conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | Internal Region |
| Specificity | Specific for DOC2B. |
Additional Info
| Function | Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes. |
| Protein Name | Double C2-Like Domain-Containing Protein BetaDoc2-Beta |
| Database Links | |
| Cellular Localisation | CytoplasmCytoplasmic GranuleCell MembranePeripheral Membrane ProteinTranslocates To The Plasma Membrane In A Calcium-Dependent Manner |
| Alternative Antibody Names | Anti-Double C2-Like Domain-Containing Protein Beta antibodyAnti-Doc2-Beta antibodyAnti-Doc2b antibody |
Information sourced from Uniprot.org