Anti-DNPH1 antibody [R67-1B-2] (STJA0035550)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human DNPH1
General Information
| Short Description | Rabbit monoclonal anti-DNPH1 for use in WB and IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R67-1B-2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:100-1:200 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | DNPH1 |
| Gene ID | 10591 |
| Uniprot ID | DNPH1_HUMAN |
| Immunogen | A synthesized peptide derived from human DNPH1 |
Additional Info
| Tissue Specificity | Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus. Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers. |
| Function | Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration. |
| Protein Name | 5-Hydroxymethyl-Dump N-Hydrolase2'-Deoxynucleoside 5'-Phosphate N-Hydrolase 1C-Myc-Responsive Protein Rcl |
| Database Links | Reactome: R-HSA-74259 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-5-Hydroxymethyl-Dump N-Hydrolase antibodyAnti-2'-Deoxynucleoside 5'-Phosphate N-Hydrolase 1 antibodyAnti-C-Myc-Responsive Protein Rcl antibodyAnti-DNPH1 antibodyAnti-C6orf108 antibodyAnti-RCL antibody |
Information sourced from Uniprot.org