Anti-DNPH1 antibody [PT0792R] (STJA0039353)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgGk
General Information
| Short Description | Rabbit monoclonal anti-5-Hydroxymethyl-Dump N-Hydrolase for use in WB and IHC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PT0792R |
| Isotype | IgGk |
| Conjugation | Unconjugated |
| Purification | Protein A |
| Dilution Range | WB 1:1000-5000IHC 1:100-300 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DNPH1 |
| Gene ID | 10591 |
| Uniprot ID | DNPH1_HUMAN |
| Specificity | Endogenous |
Additional Info
| Function | Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration. |
| Protein Name | 5-Hydroxymethyl-Dump N-Hydrolase2'-Deoxynucleoside 5'-Phosphate N-Hydrolase 1C-Myc-Responsive Protein Rcl |
| Database Links | Reactome: R-HSA-74259 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-5-Hydroxymethyl-Dump N-Hydrolase antibodyAnti-2'-Deoxynucleoside 5'-Phosphate N-Hydrolase 1 antibodyAnti-C-Myc-Responsive Protein Rcl antibodyAnti-DNPH1 antibodyAnti-C6orf108 antibodyAnti-RCL antibody |
Information sourced from Uniprot.org