Anti-Dnmt3b antibody (50-100) {Biotin} (STJ506258)

SKU:
STJ506258-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Dnmt3b (50-100) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 Mu g/Mu l
Dilution Range: ELISA 1:10, 000
ICC 1:50-1:100
IF 1:50-1:100
IHC 1:50-1:100
IP 1:200
WB 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Dnmt3b
Gene ID: 13436
Uniprot ID: DNM3B_MOUSE
Immunogen Region: 50-100
Immunogen: Synthetic peptide corresponding to amino acids within region 50-100 on mouse DNA (cytosine-5)-methyltransferase 3B protein.
Function Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells.
Protein Name Dna
Cytosine-5-Methyltransferase 3b
Dnmt3b
Dna Methyltransferase Mmuiiib
Dna Mtase Mmuiiib
M.mmuiiib
Database Links Reactome: R-MMU-212300
Reactome: -MMU-4655427
Cellular Localisation Nucleus
Accumulates In The Major Satellite Repeats At Pericentric Heterochromatin
Alternative Antibody Names Anti-Dna antibody
Anti-Cytosine-5-Methyltransferase 3b antibody
Anti-Dnmt3b antibody
Anti-Dna Methyltransferase Mmuiiib antibody
Anti-Dna Mtase Mmuiiib antibody
Anti-M.mmuiiib antibody
Anti-Dnmt3b antibody

Information sourced from Uniprot.org

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