Anti-DNER antibody (140-240) (STJ117746)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DNER (140-240) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DNER |
| Gene ID | 92737 |
| Uniprot ID | DNER_HUMAN |
| Immunogen Region | 140-240 |
| Immunogen Sequence | PATGWTESMAPRQLQPVPAT QEPDKILPRSQATVTLPTWQ PKTGQKVVEMKWDQVEVIPD IACGNASSNSSAGGRLVSFE VPQNTSVKIRQDATASLILL W |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 140-240 of human DNER (NP_620711.3). |
Additional Info
| Tissue Specificity | Expressed in brain, spinal cord and adrenal gland. |
| Function | Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis. |
| Protein Name | Delta And Notch-Like Epidermal Growth Factor-Related Receptor |
| Database Links | Reactome: R-HSA-2122948 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPresent On The Membrane Of Dendrites And Cell Bodies But Excluded From Axonal MembraneAlso Found In Early Endosomes In The Somatodendritic Region |
| Alternative Antibody Names | Anti-Delta And Notch-Like Epidermal Growth Factor-Related Receptor antibodyAnti-DNER antibodyAnti-BET antibodyAnti-UNQ262 antibodyAnti-PRO299 antibody |
Information sourced from Uniprot.org