Anti-DNAL1 antibody (41-190) (STJ110566)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DNAL1 (41-190) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DNAL1 |
| Gene ID | 83544 |
| Uniprot ID | DNAL1_HUMAN |
| Immunogen Region | 41-190 |
| Immunogen Sequence | DASLSMLANCEKLSLSTNCI EKIANLNGLKNLRILSLGRN NIKNLNGLEAVGDTLEELWI SYNFIEKLKGIHIMKKLKIL YMSNNLVKDWAEFVKLAELP CLEDLVFVGNPLEEKHSAEN NWIEEATKRVPKLKKLDGTP VIKGDEEEDN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 41-190 of human DNAL1 (NP_113615.2). |
Additional Info
| Tissue Specificity | Expressed in tissues carrying motile cilia such as respiratory epithelia, ependyma and testis. |
| Function | Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency. Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme. Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry. |
| Protein Name | Dynein Axonemal Light Chain 1Lc1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCilium Axoneme |
| Alternative Antibody Names | Anti-Dynein Axonemal Light Chain 1 antibodyAnti-Lc1 antibodyAnti-DNAL1 antibodyAnti-C14orf168 antibody |
Information sourced from Uniprot.org