Anti-DNAL1 antibody (1-190aa) [AT29E4] (STJA0041678)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenRecombinant human DNAL1 (1-190aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-DNAL1 (1-190aa) for use in ELISA, WB, ICC, IF and FACS in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF/FACS |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT29E4 |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DNAL1 |
| Gene ID | 83544 |
| Uniprot ID | DNAL1_HUMAN |
| Accession Number | NP_113615 |
| Immunogen | Recombinant human DNAL1 (1-190aa) purified from E. coli |
| Immunogen Region | 1-190aa |
Additional Info
| Tissue Specificity | Expressed in tissues carrying motile cilia such as respiratory epithelia, ependyma and testis. |
| Function | Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency. Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme. Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry. |
| Protein Name | Dynein Axonemal Light Chain 1Lc1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCilium Axoneme |
| Alternative Antibody Names | Anti-Dynein Axonemal Light Chain 1 antibodyAnti-Lc1 antibodyAnti-DNAL1 antibodyAnti-C14orf168 antibody |
Information sourced from Uniprot.org