Anti-Phospho-DNAJC2-Ser47 antibody (STJ196286)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized phosho peptide around human DNAJC2 and MPP11 (Ser47)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-DnaJ homolog subfamily C member 2-Ser47 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DNAJC2 |
| Gene ID | 27000 |
| Uniprot ID | DNJC2_HUMAN |
| Immunogen | Synthesized phosho peptide around human DNAJC2 and MPP11 (Ser47) |
| Specificity | This antibody detects endogenous levels of Human Mouse Rat DNAJC2/MPP11 (phospho-Ser47) |
Additional Info
| Post Translational Modifications | Phosphorylated in M (mitotic) phase. |
| Function | Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. |
| Protein Name | Dnaj Homolog Subfamily C Member 2M-Phase Phosphoprotein 11Zuotin-Related Factor 1 Cleaved Into - Dnaj Homolog Subfamily C Member 2 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-3371453 |
| Cellular Localisation | NucleusCytoplasmCytosol |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily C Member 2 antibodyAnti-M-Phase Phosphoprotein 11 antibodyAnti-Zuotin-Related Factor 1 Cleaved Into - Dnaj Homolog Subfamily C Member 2 - N-Terminally Processed antibodyAnti-DNAJC2 antibodyAnti-MPHOSPH11 antibodyAnti-MPP11 antibodyAnti-ZRF1 antibody |
Information sourced from Uniprot.org