| Post Translational Modifications | Phosphorylated in M (mitotic) phase. |
| Function | Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. |
| Protein Name | Dnaj Homolog Subfamily C Member 2M-Phase Phosphoprotein 11Zuotin-Related Factor 1 Cleaved Into - Dnaj Homolog Subfamily C Member 2 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-3371453 |
| Cellular Localisation | NucleusCytoplasmCytosol |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily C Member 2 antibodyAnti-M-Phase Phosphoprotein 11 antibodyAnti-Zuotin-Related Factor 1 Cleaved Into - Dnaj Homolog Subfamily C Member 2 - N-Terminally Processed antibodyAnti-DNAJC2 antibodyAnti-MPHOSPH11 antibodyAnti-MPP11 antibodyAnti-ZRF1 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and DNAJC2 knockout (KO) 293T cells, using [KO Validated] DNAJC2 Rabbit polyclonal antibody (STJ11100830) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89766/358240/STJ11100830_1__88794.1713122573.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and DNAJC2 knockout (KO) 293T cells, using [KO Validated] DNAJC2 Rabbit polyclonal antibody (STJ11100830) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
