Anti-DNAJC2 antibody (406-456 aa) (STJ192936)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein at the amino acid range 406-456
General Information
| Short Description | Rabbit polyclonal anti-DnaJ homolog subfamily C member 2 (406-456 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DNAJC2 |
| Gene ID | 27000 |
| Uniprot ID | DNJC2_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein at the amino acid range 406-456 |
| Immunogen Region | 406-456 aa |
| Specificity | DNJC2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylated in M (mitotic) phase. |
| Function | Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. |
| Protein Name | Dnaj Homolog Subfamily C Member 2M-Phase Phosphoprotein 11Zuotin-Related Factor 1 Cleaved Into - Dnaj Homolog Subfamily C Member 2 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-3371453 |
| Cellular Localisation | NucleusCytoplasmCytosol |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily C Member 2 antibodyAnti-M-Phase Phosphoprotein 11 antibodyAnti-Zuotin-Related Factor 1 Cleaved Into - Dnaj Homolog Subfamily C Member 2 - N-Terminally Processed antibodyAnti-DNAJC2 antibodyAnti-MPHOSPH11 antibodyAnti-MPP11 antibodyAnti-ZRF1 antibody |
Information sourced from Uniprot.org