| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DNAJC10 (614-793) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DNAJC10 |
| Gene ID: |
54431 |
| Uniprot ID: |
DJC10_HUMAN |
| Immunogen Region: |
614-793 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 614-793 of human DNAJC10 (NP_061854.1). |
| Immunogen Sequence: |
IDCQQYHSFCAQENVQRYPE IRFFPPKSNKAYHYHSYNGW NRDAYSLRIWGLGFLPQVST DLTPQTFSEKVLQGKNHWVI DFYAPWCGPCQNFAPEFELL ARMIKGKVKAGKVDCQAYAQ TCQKAGIRAYPTVKFYFYER AKRNFQEEQINTRDAKAIAA LISEKLETLRNQGKRNKDEL |
| Function | Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. |
| Protein Name | Dnaj Homolog Subfamily C Member 10Endoplasmic Reticulum Dna J Domain-Containing Protein 5Er-Resident Protein Erdj5Erdj5MacrothioredoxinMthr |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily C Member 10 antibodyAnti-Endoplasmic Reticulum Dna J Domain-Containing Protein 5 antibodyAnti-Er-Resident Protein Erdj5 antibodyAnti-Erdj5 antibodyAnti-Macrothioredoxin antibodyAnti-Mthr antibodyAnti-DNAJC10 antibodyAnti-ERDJ5 antibodyAnti-UNQ495 antibodyAnti-PRO1012 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
