Anti-DNAJA3 antibody (STJA0009589)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human TID1
General Information
| Short Description | Rabbit polyclonal anti-DnaJ homolog subfamily A member 3, mitochondrial for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DNAJA3 |
| Gene ID | 9093 |
| Uniprot ID | DNJA3_HUMAN |
| Immunogen | Synthesized peptide derived from human TID1 |
| Specificity | This antibody detects endogenous levels of TID1 at Human, Mouse |
Additional Info
| Post Translational Modifications | Tyrosine phosphorylated. |
| Function | Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C.in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. |
| Protein Name | Dnaj Homolog Subfamily A Member 3 - MitochondrialDnaj Protein Tid-1Htid-1Hepatocellular Carcinoma-Associated Antigen 57Tumorous Imaginal Discs Protein Tid56 Homolog |
| Database Links | |
| Cellular Localisation | Mitochondrion MatrixCytoplasmCytosolPostsynaptic Cell MembranePeripheral Membrane ProteinRecruited To The Postsynaptic Cell Membrane Of The Neuromuscular Junction Through Interaction With Musk |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily A Member 3 - Mitochondrial antibodyAnti-Dnaj Protein Tid-1 antibodyAnti-Htid-1 antibodyAnti-Hepatocellular Carcinoma-Associated Antigen 57 antibodyAnti-Tumorous Imaginal Discs Protein Tid56 Homolog antibodyAnti-DNAJA3 antibodyAnti-HCA57 antibodyAnti-TID1 antibody |
Information sourced from Uniprot.org