Anti-DNAJA3 antibody (221-480) (STJ29110)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DNAJA3 (221-480) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DNAJA3 |
| Gene ID | 9093 |
| Uniprot ID | DNJA3_HUMAN |
| Immunogen Region | 221-480 |
| Immunogen Sequence | AKGVNKEFTVNIMDTCERCN GKGNEPGTKVQHCHYCGGSG METINTGPFVMRSTCRRCGG RGSIIISPCVVCRGAGQAKQ KKRVMIPVPAGVEDGQTVRM PVGKREIFITFRVQKSPVFR RDGADIHSDLFISIAQALLG GTARAQGLYETINVTIPPGT QTDQKIRMGGKGIPRINSYG YGDHYIHIKIRVPKRLTSRQ QSLILSYAEDETDVEGTVNG VTLTSSGGSTMDSSAGSKA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 221-480 of human DNAJA3 (NP_005138.3). |
Additional Info
| Tissue Specificity | Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.expression level and distribution is altered in basal cell carcinomas. |
| Post Translational Modifications | Tyrosine phosphorylated. |
| Function | Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C.in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. |
| Protein Name | Dnaj Homolog Subfamily A Member 3 - MitochondrialDnaj Protein Tid-1Htid-1Hepatocellular Carcinoma-Associated Antigen 57Tumorous Imaginal Discs Protein Tid56 Homolog |
| Database Links | |
| Cellular Localisation | Mitochondrion MatrixCytoplasmCytosolPostsynaptic Cell MembranePeripheral Membrane ProteinRecruited To The Postsynaptic Cell Membrane Of The Neuromuscular Junction Through Interaction With Musk |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily A Member 3 - Mitochondrial antibodyAnti-Dnaj Protein Tid-1 antibodyAnti-Htid-1 antibodyAnti-Hepatocellular Carcinoma-Associated Antigen 57 antibodyAnti-Tumorous Imaginal Discs Protein Tid56 Homolog antibodyAnti-DNAJA3 antibodyAnti-HCA57 antibodyAnti-TID1 antibody |
Information sourced from Uniprot.org