| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DNAJA3 (221-480) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DNAJA3 |
| Gene ID: |
9093 |
| Uniprot ID: |
DNJA3_HUMAN |
| Immunogen Region: |
221-480 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 221-480 of human DNAJA3 (NP_005138.3). |
| Immunogen Sequence: |
AKGVNKEFTVNIMDTCERCN GKGNEPGTKVQHCHYCGGSG METINTGPFVMRSTCRRCGG RGSIIISPCVVCRGAGQAKQ KKRVMIPVPAGVEDGQTVRM PVGKREIFITFRVQKSPVFR RDGADIHSDLFISIAQALLG GTARAQGLYETINVTIPPGT QTDQKIRMGGKGIPRINSYG YGDHYIHIKIRVPKRLTSRQ QSLILSYAEDETDVEGTVNG VTLTSSGGSTMDSSAGSKA |
| Tissue Specificity | Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes. |
| Post Translational Modifications | Tyrosine phosphorylated. |
| Function | Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C.in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. |
| Protein Name | Dnaj Homolog Subfamily A Member 3 - MitochondrialDnaj Protein Tid-1Htid-1Hepatocellular Carcinoma-Associated Antigen 57Tumorous Imaginal Discs Protein Tid56 Homolog |
| Cellular Localisation | Mitochondrion MatrixCytoplasmCytosolPostsynaptic Cell MembranePeripheral Membrane ProteinRecruited To The Postsynaptic Cell Membrane Of The Neuromuscular Junction Through Interaction With Musk |
| Alternative Antibody Names | Anti-Dnaj Homolog Subfamily A Member 3 - Mitochondrial antibodyAnti-Dnaj Protein Tid-1 antibodyAnti-Htid-1 antibodyAnti-Hepatocellular Carcinoma-Associated Antigen 57 antibodyAnti-Tumorous Imaginal Discs Protein Tid56 Homolog antibodyAnti-DNAJA3 antibodyAnti-HCA57 antibodyAnti-TID1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
