Anti-DMRT1 antibody (STJA0037902)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human DMRT1
General Information
| Short Description | Rabbit monoclonal anti-DMRT1 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | IHC 1:100-1:200 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | DMRT1 |
| Gene ID | 1761 |
| Uniprot ID | DMRT1_HUMAN |
| Immunogen | A synthesized peptide derived from human DMRT1 |
Additional Info
| Tissue Specificity | Testis-specific. Expressed in prostate cancer (at protein level). |
| Function | Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis. |
| Protein Name | Doublesex- And Mab-3-Related Transcription Factor 1Dm Domain Expressed In Testis Protein 1 |
| Database Links | Reactome: R-HSA-9690406 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Doublesex- And Mab-3-Related Transcription Factor 1 antibodyAnti-Dm Domain Expressed In Testis Protein 1 antibodyAnti-DMRT1 antibodyAnti-DMT1 antibody |
Information sourced from Uniprot.org