| Function | Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis. |
| Protein Name | Doublesex- And Mab-3-Related Transcription Factor 1Dm Domain Expressed In Testis Protein 1 |
| Database Links | Reactome: R-HSA-9690406 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Doublesex- And Mab-3-Related Transcription Factor 1 antibodyAnti-Dm Domain Expressed In Testis Protein 1 antibodyAnti-DMRT1 antibodyAnti-DMT1 antibody |
Information sourced from Uniprot.org
