| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DMRT1 (134-373) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DMRT1 |
| Gene ID: |
1761 |
| Uniprot ID: |
DMRT1_HUMAN |
| Immunogen Region: |
134-373 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 134-373 of human DMRT1 (NP_068770.2). |
| Immunogen Sequence: |
SHPIPLPSAAELLVKRENNG SNPCLMTECSGTSQPPPASV PTTAASEGRMVIQDIPAVTS RGHVENTPDLVSDSTYYSSF YQPSLFPYYNNLYNCPQYSM ALAADSASGEVGNPLGGSPV KNSLRGLPGPYVPGQTGNQW QMKNMENRHAMSSQYRMHSY YPPPSYLGQSVPQFFTFEDA PSYPEARASVFSPPSSQDSG LVSLSSSSPISNKSTKAVLE CEPASEPSSFTVTPVIEED |
| Tissue Specificity | Testis-specific. Expressed in prostate cancer (at protein level). |
| Function | Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis. |
| Protein Name | Doublesex- And Mab-3-Related Transcription Factor 1Dm Domain Expressed In Testis Protein 1 |
| Database Links | Reactome: R-HSA-9690406 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Doublesex- And Mab-3-Related Transcription Factor 1 antibodyAnti-Dm Domain Expressed In Testis Protein 1 antibodyAnti-DMRT1 antibodyAnti-DMT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
