Anti-DMRT1 antibody (134-373) (STJ110709)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DMRT1 (134-373) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DMRT1 |
| Gene ID | 1761 |
| Uniprot ID | DMRT1_HUMAN |
| Immunogen Region | 134-373 |
| Immunogen Sequence | SHPIPLPSAAELLVKRENNG SNPCLMTECSGTSQPPPASV PTTAASEGRMVIQDIPAVTS RGHVENTPDLVSDSTYYSSF YQPSLFPYYNNLYNCPQYSM ALAADSASGEVGNPLGGSPV KNSLRGLPGPYVPGQTGNQW QMKNMENRHAMSSQYRMHSY YPPPSYLGQSVPQFFTFEDA PSYPEARASVFSPPSSQDSG LVSLSSSSPISNKSTKAVLE CEPASEPSSFTVTPVIEED |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 134-373 of human DMRT1 (NP_068770.2). |
Additional Info
| Tissue Specificity | Testis-specific. Expressed in prostate cancer (at protein level). |
| Function | Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis. |
| Protein Name | Doublesex- And Mab-3-Related Transcription Factor 1Dm Domain Expressed In Testis Protein 1 |
| Database Links | Reactome: R-HSA-9690406 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Doublesex- And Mab-3-Related Transcription Factor 1 antibodyAnti-Dm Domain Expressed In Testis Protein 1 antibodyAnti-DMRT1 antibodyAnti-DMT1 antibody |
Information sourced from Uniprot.org