Anti-DMP1 antibody (1-100) (STJ119193)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DMP1 (1-100) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DMP1 |
| Gene ID | 1758 |
| Uniprot ID | DMP1_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MKISILLMFLWGLSCALPVT RYQNNESEDSEEWKGHLAQA PTPPLESSESSEGSKVSSEE QANEDPSDSTQSEEGLGSDD HQYIYRLAGGFSRSTGKGGD |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DMP1 (NP_004398.1). |
Additional Info
| Tissue Specificity | Expressed in tooth particularly in odontoblast, ameloblast and cementoblast. |
| Post Translational Modifications | Phosphorylated in the cytosol and extracellular matrix and unphosphorylated in the nucleus. Phosphorylation is necessary for nucleocytoplasmic transport and may be catalyzed by a nuclear isoform of CK2 and can be augmented by calcium. Phosphorylated (in vitro) by FAM20C in the extracellular medium at sites within the S-x-E/pS motif. |
| Function | May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. |
| Protein Name | Dentin Matrix Acidic Phosphoprotein 1Dmp-1Dentin Matrix Protein 1 |
| Database Links | Reactome: R-HSA-3000178Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | NucleusCytoplasmSecretedExtracellular SpaceExtracellular MatrixIn Proliferating Preosteoblasts It Is NuclearDuring Early Maturation Stage Is Cytoplasmic And In Mature Osteoblast Localizes In The Mineralized MatrixExport From The Nucleus Of Differentiating Osteoblast Is Triggered By The Release Of Calcium From Intracellular Stores Followed By A Massive Influx Of This Pool Of Calcium Into The Nucleus |
| Alternative Antibody Names | Anti-Dentin Matrix Acidic Phosphoprotein 1 antibodyAnti-Dmp-1 antibodyAnti-Dentin Matrix Protein 1 antibodyAnti-DMP1 antibody |
Information sourced from Uniprot.org