Anti-DMAP1 antibody [R03-8Z7] (STJA0037455)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human DMAP1
General Information
| Short Description | Rabbit monoclonal anti-DMAP1 for use in WB, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-8Z7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | DMAP1 |
| Gene ID | 55929 |
| Uniprot ID | DMAP1_HUMAN |
| Immunogen | A synthesized peptide derived from human DMAP1 |
Additional Info
| Function | Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. |
| Protein Name | Dna Methyltransferase 1-Associated Protein 1Dnmap1Dnmt1-Associated Protein 1 |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | NucleusCytoplasmTargeted To Replication Foci Throughout S Phase By Dnmt1 |
| Alternative Antibody Names | Anti-Dna Methyltransferase 1-Associated Protein 1 antibodyAnti-Dnmap1 antibodyAnti-Dnmt1-Associated Protein 1 antibodyAnti-DMAP1 antibodyAnti-KIAA1425 antibody |
Information sourced from Uniprot.org