Anti-DLST antibody [SRM15015] (STJ11109745)

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STJ11109745
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Host: Rabbit
Applications: WB/IF/ICC/IHC-P/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : SRM15015
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity purification
Dilution Range: WB, 1:12000-1:72000
IF/ICC, 1:100-1:400
IHC-P, 1:2000-1:20000
ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DLST
Gene ID: 1743
Uniprot ID: ODO2_HUMAN
Immunogen: Synthetic peptide. This information is considered to be commercially sensitive.
Function Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.
Protein Name Dihydrolipoyllysine-Residue Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex - Mitochondrial
2-Oxoglutarate Dehydrogenase Complex Component E2
Ogdc-E2
Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex
E2k
Database Links Reactome: R-HSA-6783984
Reactome: R-HSA-9853506
Reactome: R-HSA-9857492
Reactome: R-HSA-9858328
Cellular Localisation Mitochondrion Matrix
Nucleus
Mainly Localizes In The Mitochondrion
A Small Fraction Localizes To The Nucleus
Where The 2-Oxoglutarate Dehydrogenase Complex Is Required For Histone Succinylation
Alternative Antibody Names Anti-Dihydrolipoyllysine-Residue Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex - Mitochondrial antibody
Anti-2-Oxoglutarate Dehydrogenase Complex Component E2 antibody
Anti-Ogdc-E2 antibody
Anti-Dihydrolipoamide Succinyltransferase Component Of 2-Oxoglutarate Dehydrogenase Complex antibody
Anti-E2k antibody
Anti-DLST antibody
Anti-DLTS antibody

Information sourced from Uniprot.org

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