Anti-DLG5 antibody (C-Term) (STJ13101046)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide to the c-terminal region of human Disks large homolog 5 (DLG5) conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-DLG5 (C-Term) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | DLG5 |
| Gene ID | 9231 |
| Uniprot ID | DLG5_HUMAN |
| Immunogen | A synthetic peptide to the c-terminal region of human Disks large homolog 5 (DLG5) conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | C-Term |
| Specificity | Specific for DLG5. |
Additional Info
| Function | Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1. Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion. Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons.regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation. |
| Protein Name | Disks Large Homolog 5Discs Large Protein P-DlgPlacenta And Prostate Dlg |
| Database Links | Reactome: R-HSA-9013420Reactome: R-HSA-9013424Reactome: R-HSA-9696264Reactome: R-HSA-9696270Reactome: R-HSA-9696273 |
| Cellular Localisation | Cell JunctionCell MembranePeripheral Membrane ProteinPostsynaptic DensityCytoplasmCytoskeletonCilium Basal BodyLocalized At Sites Of Cell-Cell Contact |
| Alternative Antibody Names | Anti-Disks Large Homolog 5 antibodyAnti-Discs Large Protein P-Dlg antibodyAnti-Placenta And Prostate Dlg antibodyAnti-DLG5 antibodyAnti-KIAA0583 antibodyAnti-PDLG antibody |
Information sourced from Uniprot.org